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GermanyMainz and Rheinland-Pfalz

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Sodium Borohydride is a versatile and selective reducing agent that has a variety of applications in manufacturing of pharmaceutical active ingredients, crop protection agents, aroma compounds and other fine chemicals. Its CAS-N° reads [16940-66-2]. Typical applications are: Reduction of Aldehydes / Acid Chlorides / Anhydrides to primary Alcohols; Reduction of Ketones to secondary Alcohols; Reduction of Imines to Amines; Removing impurities and purification of process streams; Metal ion reduction / Noble metal recovery / Dehalogenations. Sodium Borohydride is due to its reactivity a hazardous compound under dangerous goods regulation which requires specific storage. Our material is usually promptly available from stock for industrial consumers, To influence reactivity and handling comfort the product is available as coarse powder, fine powder and as granules. Detailed specification, material safety data sheet and additional documents are available on request.

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Diethylpropion hydrochloride is an amphetamine derivative that acts systemically on the cardiovascular system, certain organs and the brain (or CNS) as an indirect α-sympathomimetic. It is counted among the psychostimulants and suppresses needs such as sleep, appetite, thirst and urination. The release of catecholamines (e.g. adrenaline, dopamine) increases heart rate, blood pressure and pulmonary circulation. It is used to treat obesity.

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Pipamperone 2HCl is an active pharmaceutical ingredient manufactured following the EU-GMP regulations. We offer the API following EU-GMP (ICH Q7) regulations with an active ASMF. Material is availalbe upon request from stock. The active ingredient is used as an antipsychotic and sedative. It works mainly on the serotonin and dopamine receptors. The sedative effect outweighs that of the antipsychotic. Pipamperone regulates internal restlessness, sleep disturbances, and also weakens arousal conditions, as well as aggressiveness.

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Ketoprofen is a synthetically synthesized Active Pharmaceutical Ingredient, produced under cGMP, compliant with EP, JP monographs. Its CAS-N° reads 22071-15-4. It is used in treatment of arthritis-related inflammatory pains, severe toothaches that result in the inflammation of the gums or nerve pain. Ketoprofen is an acidic, non-opioid analgesic used for pain and inflammation. By inhibiting prostaglandin synthesis at the key enzyme cyclooxygenase, it can be used for acute and chronic pain (e.g. arthrosis and arthritides). Like most active ingredients in its class, it is poorly tolerated by the gastrointestinal tract, a particular side effect is light sensitization. Detailed specification, Certificate of Analysis and samples are available on request.

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Enzalutamide binds to androgen receptors and thereby inhibits them (antiandrogen). In addition, translocation in the cell nuclei is inhibited and the binding to the DNA is weakened, as well as the recruitment of cofactors for transcription. This leads to the inhibition of gene expression, which are regulated by the androgen receptors. Due to the triple mechanism of action, Enzalutamide differs from the usual anti-androgenic substances. Due to its anti-androgenic properties, the active ingredient also has an antineoplastic effect in androgen-sensitive tumors (e.g. metastatic prostate cancer).

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Zofenopril calcium is an inhibitor of the angiotensin-converting enzyme (ACE inhibitor). Angiotensin I & II control the tone of the blood vessels and are part of the Renin Angiotensin aldosterone system. The increase in angiotensin II leads to a reduction in vascular tone, which leads to lower blood pressure. Therefore, it is used in the therapy of arterial hypertension and acute heart attacks.

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Doxapram hydrochloride is a synthetically synthesized Active Pharmaceutical Ingredient, produced under cGMP, compliant with EP, USP, JP, ANVISA monographs. Its CAS-N° reads 7081-53-0. It is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of specific other drugs. Detailed specification, Certificate of Analysis and samples are available on request.

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Crotamiton is an active pharmaceutical ingredient produced under cGMP. * only European manufacturer * competitive process * up-to-date documentation * starting materials sourced from EU (no dependence on China) Crotamitone is an antipruriginosum used to treat burial mites (scabies). It works against the mites themselves, but also against the itching.

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Warfarin Sodium, amorphous is a synthetically synthesized Active Pharmaceutical Ingredient, produced under cGMP, compliant with EP monograph. Its CAS-N° reads [129-06-6]. It is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions. Detailed specification, Certificate of Analysis and samples are available on request. Warfarin sodium is a 4-hydroxycumarin, these are known as vitamin K antagonists. Vitamin K antagonists are anticoagulants that encroach on the blood clotting cascade. Since the substance can have significant fluctuations in its effectiveness, depending on the genotype, the blood clotting levels for dose tuning should be tested regularly.

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Trospium chloride is a synthetic API, produced under cGMP. Its quality complies with International Monographs such as European Pharmacopoeia (EP) or US-Pharmacopoeia (USP). CAS number is [10405-02-4]. Trospium chloride is a tropane derivative (3α-nortropanol benzene acid ester) and an anticholinergic agent. This is used to treat urge and reflex incontinence. This is achieved by the competitive blockage of acetylcholine on their receptors. This inhibits the parasympathetic influence, smooth muscles, heart muscle and parts of the peripheral nervous system. Detailed specification, certificates of analysis and samples are available on request.

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Clofazimin is considered one of the cationic amphiphic medicines. The mechanism of action is not fully understood. Clofamizin is a red dye that has a bacteriostatic effect on the leprosy causing mycobacterium leprae. The active ingredient is used by WHO to treat leprosy.

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Propofol belongs to the group of phenol derivatives. The active substance is a short-acting anesthetic. It is used for the initiation and maintenance of intravenous anesthesia.

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Germany

Advantages • Quick throughput times, high processing exactness as well as improved working conditions through optimally planned material flow • Compatible components reduce interfaces • Large assortment of standard components: Belt Conveyors: • Curved Belt Conveyors • Small Belt Conveyors • Inclined Belt conveyors Roller Conveyors: • Wheel Conveyors • Light Roller Conveyors • Roller Conveyor Curves • Gravity Roller Conveyors • Driven Roller Conveyors Chain Conveyors: • Chain Conveyors • Traction Lifts Product transportation is an essential element of in-plant logistics. Exact and precise handling is a prerequisite for optimal material flow. Belt conveyors are ideal for transporting light to moderately heavy products. Roller conveyors can be adapted to a variety of space conditions. They are used for transporting light as well as heavy products, are impervious to dust and thus ideal for use in dusty environments.

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