BIOSUPPLY UK

BioSupply offers a highly sensitive and specific adiponectin ELISA kit. This assay provides a dynamic range of 2-100ng/ml and it can reach minimum sensitivity detection limits of 0.6ng/ml. Adiponectin is predominately produced through adipocytes, however, recently there is evidence to indicate muscle cells and hepatocytes may also be able to synthesis it. There is a negative correlation between the concentration of adiponectin and the concentrations of insulin, glucose, triglyceride, fat content. Adiponectin is a member of the soluble defence collagen superfamily of proteins, consisting of a collagen-like domain which is structurally similar to that found in collagen VII, C1q-like globular domain and collagen X. For more information on this product, please visit our website: http://www.elisakits.co.uk/adiponectin-elisa-kit/

BioSupply offers a highly sensitive and specific SAA ELISA kit. This assay provides a dynamic range of 1.1-80ng/ml and it can reach minimum sensitivity detection limits of < 1.1ng/ml. Serum amyloid A is an acute-phase protein which can exist as many different polymorphic forms (SAA1 to SAA4). Generally, SAA circulates at trace levels and then become elevate in response to an inflammatory stimulus. There have been many cytokines (for example: TNF, IL-1 and IL-6) that have been identified which can mediate the synthesis of SAA protein. Serum amyloid A is a marker for many inflammatory stimulus and can be a useful indicator to the level of inflammation present in patients suffering from either acute or chronic inflammation. It can also be vital in detecting the response to any potential treatment therapy. For more information on this product, please visit our website: http://www.elisakits.co.uk/serum-amyloid-a-saa-elisa-kit/

BioSupply offers a highly sensitive and specific MMP-3 ELISA kit. This assay provides a dynamic range of 0.156-10ng/mL and it can reach minimum sensitivity detection limits of 0.068ng/mL. Matrix metalloproteinase-3 has a total molecular weight of 54kDa and it is 477 residues in length which also consists of a signal peptide. MMP-3 is a proteoglycanase which has a major role in degrading fibronectin, laminin, proteoglycans, elastin and collagen. Matrix metalloproteinase-3 is also able to activate many other MMPs during process such as: wound repair, progression of atherosclerosis, connective tissue remodelling and tumor initiation. For more information on this product, please visit our website: http://www.elisakits.co.uk/matrix-metalloproteinase-3-mmp-3-elisa-kit/

BioSupply offers a highly sensitive and specific cortisol ELISA kit. This assay provides a dynamic range of 10-800ng/ml and it can reach minimum sensitivity detection limits of 3.79ng/ml. Cortisol is synthesised within the adrenal cortex in the zona reticularis or the zona fasciculate regions. Some of the biological effects that are the result of cortisol include: promotion of gluconeogenesis, deposition of liver glycogen, increase in blood glucose concentration, anti-inflammatory action and effect on fat metabolism. The detection of cortisol can be a fundamental marker for diseases which can lead to the abnormal production of glucocorticoid. For more information on this product, please visit our website: http://www.elisakits.co.uk/cortisol-elisa-kit/

BioSupply offers a highly sensitive and specific cadherin-11 ELISA kit. This assay provides a dynamic range of 0.5-20.0ng/ml and it can reach minimum sensitivity detection limits of 0.025ng/ml. Cadherin-11 which is also referred to as CAD11 or CDH11 for short, is essentially made up of a single membrane spanning domain, N-terminal extracellular domain and a cytoplasmic C-terminal that is highly conserved. The full length cadherin-11 of mouse and human display around 97% amino acid homology. It is found to be expressed in a large number of normal tissues which are predominately mesodermal for example: osteoblasts, kidney and brain. The ability to upregulate during osteoblastic cell line differentiation may indicate a role for cadherin-11 in bone development and maintenance. For more information on this product, please visit our website: http://www.elisakits.co.uk/cadherin-11-cdh11-elisa-kit/

BioSupply offers a highly sensitive and specific interleukin-4 ELISA kit. This assay provides a dynamic range of 15.6-1,000pg/ml and it can reach minimum sensitivity detection limits of < 1.5pg/ml. IL-4 gene is present on chromosome 5 and the human cDNA encodes a 153 amino acid protein which also consists of a putative signal peptide. Interleukin-4 is often describe as a pleiotropic cytokine due to its ability to modulate the functions many cell types during different immune responses. There are evidence to indicate that IL-4 can produce cells such as: TH2, CD8+ T cells, mast cells, CD4+ TH0, basophils and fetal thymocytes. IL-4 is crucially an immunomodulatory cytokine which can also inhibit tumor cell growth. For more information on this product, please visit our website: http://www.elisakits.co.uk/interleukin-4-il-4-elisa-kit/

BioSupply offers a highly sensitive and specific MMP-8 ELISA kit. This assay provides a dynamic range of 0.05-10ng/mL and it can reach minimum sensitivity detection limits of 0.021ng/mL. Matrix metalloproteinase-8 is a specific collagen cleaving enzyme that is found to be highly expressed in leukocytes cells and chorionic cytotrophoblast. MMP-8 levels have also been found to be elevated in Rheumatoid Arthritis patients. There is evidence to indicate that many active forms of this enzyme can be created which contain distinct N-termini due to proteolysis occurring at different sites on this protein. For more information on this product, please visit our website: http://www.elisakits.co.uk/matrix-metalloproteinase-8-mmp-8-elisa-kit/

BioSupply offers a highly sensitive and specific insulin ELISA kit. This assay provides a dynamic range of 0.25-200µIU/ml and it can reach minimum sensitivity detection limits of 0.25µIU/ml. Insulin has a total molecular weight of 5800Da and it is made up of two peptides chains that are approximately 51 amino acids long. It is vital in the regulation of carbohydrate metabolism, other processes where insulin is also important include: gluconeogenesis, lipolysis, decreased proteinolysis, fatty acid synthesis, increased protein synthesis and DNA replication, controlling glucose intake in muscles and adipose tissues. For more information on this product, please visit our website: http://www.elisakits.co.uk/insulin-elisa-kit/

BioSupply offers a highly sensitive and specific ferritin ELISA kit. This assay provides a dynamic range of 5-1,000ng/ml and it can reach minimum sensitivity detection limits of 0.53ng/ml. Ferritin consists of light and heavy subunits surrounded in a crystalline core containing iron and phosphate oxide within an apoferritin shell. The highest concentrations of ferritin can be found in the liver, spleen and bone marrow. Routine analysis of ferritin levels are recommended in order to detect early signs of iron deficiencies especially in healthy people. Since there is a direct correlation between the levels of ferritin measured and the total amount of iron which is stored in the body. This is due to the fact that within the body, iron is predominately stored complexed to either ferritin or hemosiderin. For more information on this product, please visit our website: http://www.elisakits.co.uk/ferritin-elisa-kit/

BioSupply offers a highly sensitive and specific leptin ELISA kit. This assay provides a dynamic range of 62.5-4,000pg/ml and it can reach minimum sensitivity detection limits of <10pg/ml. Leptin is a protein which is 16kDa in size and consists of a single 146 amino acid sequence, this is predominately the product of the obese gene. Whilst leptin is circulating around the body, it is abundantly expressed in the adipose tissues where it is critical in regulating appetite, fat metabolism and body weight. In humans, it has been found that the amount of leptin present is directly correlated with the percentage of body fat and BMI. Both of these factors are well known to be elevated in people who are obese. For more information on this product, please visit our website: http://www.elisakits.co.uk/leptin-elisa-kit/