COMBER Pharmadry® - Series PH 50 - PH 4000 The Pharmadry vacuum paddle dryer with short drying times is well suited for the drying of freely flowing, sensitive pharmaceutical ingredients and fine chemicals. Designed to meet stringent cGMP and FDA guidelines. Special properties for the customer’s benefit: In compliance with cGMP and FDA guidelines, also in aseptic/ steam sterilizable versions Agitator supported at the rear, with externally exchangeable mechanical seal Entirely welded agitator design, without any bolts, without pockets and with all edges rounded for good cleanability Minimal build depth, thus very good accessibility for inspection and cleaning purposes Excellent cleanability using CIP systems, simple validation Available with separating wall between process and mechanical areas Double mechanical seal, externally interchangeable, dry running contacting or non-contacting lift-off type seals as well as liquid lubricated seals
Germany
The laboratory vacuum shovel dryer DRUVATHERM® is a system provides reliable scale-up to production scales in the context of product and process development and can likewise be used for small batch production too. The Lödige laboratory vacuum shovel dryer DRUVATHERM® is a horizontal, batch vacuum dryer with a frequency-controlled mixing tool. This mixer consisting of mixing elements adapted to the process and arranged on a shaft according to a specific system - is installed in a cylindrical mixing drum equipped with a temperature control jacket. Rotation of the mixing unit generates a three-dimensional product movement, in which all of the product is constantly in motion. The contact frequency of particles with the heat exchange surface leads to shorter drying times. The chopper rotating at high speeds fitted to the side of the mixing drum is used to disperse the product . This leads to a significant increase in drying capacity and prevents moisture and temperature gradients.
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Main features • Management of the process time and temperature through the heat exchanger • Short mixing time • Extremely high mixing quality • Batches with repeatable results • Mixing ratio 1/100.000 • Coefficient of variation (CV): ≤ 3 % • Low maintenance Techanical features • Batch size: from 65 to 28.000 liters (net) • Cylindrical mixing chamber • MIxing tools: ploughshare / ploughshare with toothed design / Mix Paddle / Mix Paddle with toothed design • Material of costruction: carbon steel / Hardox 450 / AISI 304 / AISI 316 / AISI 316Ti • Inspection door complete with safety electric lock • Discharge door with round profile, building the bottom side of the mixing chamber • Rotor shaft with turned and coaxial ends • Rotor shaft sealing system with packing seals and wear resistant ferrules to protect the rotor shaft, prepared for flushing with air / nitrogen • Heat exchanger on mixing chamber for heating / cooling processes
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