ALPHA LIFETECH INC.

Alpha Lifetech Inc. has advanced experimental technology in the direction of virus, skilled in the virus isolation and culture with high success rate. Therefore, Alpha Lifetech Inc. has strong advantages in the construction of immortalized cell lines, and our success rate is higher.

To create reliable cell lines, Alpha Lifetech Inc. has developed a platform to validate the state of cell lines, including identity, growth morphology, genetic stability, tumorigenicity, sterility general virus screening, species-specific virus tests, retrovirus tests and adventitious agents from raw material.

Alpha Lifetech Inc. can offer the antibody affinity maturation service by using mutation and selection technologies. We usually use scFv as the antibody format in the processes of affinity maturation service and a monovalent display phagemid system which has been used to reduce the avidity effects during antigen-binding screening. Our professional team can provide affinity maturation services for single-domain antibodies as well.

Alpha Lifetech Inc. is capable of providing different species or different isotypes of native or synthesized Fab antibody libraries based on our mature phage display technology platform. Building up a high-quality antibody library with a large library size and high diversity has been crucial for the successful isolation of antibodies, it will result in the speed of antibody-drug discovery.

Alpha Lifetech Inc. is a well-recognized leader in the field of single domain antibody discovery. Alpha Lifetech Inc. has developed proprietary procedures for nanobody discovery. Our optimized library construction and screening processes with phage display technology guarantee successful isolation of high affinity camel nanobodies in a short time. We have successfully produced multiple positive clones for a variety of antigens, ranging from large protein molecules (>400kD) to small haptens (small chemical molecules of ~200 dalton), many of the binders have sub-nanomolar affinities measured by ELISA.

Alpha Lifetech Inc. has a comprehensive R&D platform with unsurpassed technical expertise, by which we can offer our customers the full range of mouse hybridoma development services, including antigen design, animal immunization and hybridoma characteristics, to meet their requirements for each project.

Alpha Lifetech Inc.'s custom chicken polyclonal antibody (pAbs) services including the full-service from chicken immunization, serum-collection, titer analysis, antibody production to antibody modification. IgY is the main serum immunoglobulin in chicken. Same as IgG, IgY contains two heavy and two light polypeptide chains, shaped in the Y characteristics and presents two binding sites for the antigen. But there is only a little or no immunological cross-reactivity between IgY and mammalian IgG. IgY has a relative higher molecular weight (~180kDa and ~160kDa to IgG) due to an extra constant domain in its heavy chain (H), lacks a well-defined hinge region and has an unique oligosaccharide. Alpha Lifetech Inc. can provide a complete service including antigen synthesis, modification, chicken immunization and IgY purification to produce polyclonal antibody (pAbs) in chickens.